Barbarian Main-hand and Alternating Hands Skills List

Main-hand only Skills
  • Leap
  • Ancient Spear
  • Ground Stomp -Trembling Stomp
  • Sprint -Run Like the Wind
  • Sprint -Gangway
  • Overpower
  • Revenge
  • Rend
  • Earthquake
  • Call of the Ancients
  • Wrath of the Berserker -Arreat's Wail
  • Ignore Pain -Bravado

Alternates hands Skills
  • Bash
  • Cleave
  • Frenzy
  • Furious Charge
  • Whirlwind
  • Hammer of the Ancients
  • Seismic Slam
  • Weapon Throw

General rule of thumb is, skills with cooldowns usually use main-hand only damage and skills that you can spam usually alternate. Note: One exception is Furious Charge.

Thanks to Lonewolf616 for this list!